Source comparison
Using BPC-157 for Tendon Healing Research Evidence: Research Design Comparison
Rat Achilles transection Complete tendon rupture 10 μg/kg IP daily Load-to-failure strength 78% recovery at 14d vs 52% control Biomechanical tensile testing Rat rotator cuff detachment Supraspinatus tendon-bone separation 10 μg/kg SC daily Tendon-bone integrat
This comparison does not assign a generated winner or score.
- Rat Achilles transection
- Complete tendon rupture
- 10 μg/kg IP daily
- Load-to-failure strength
- 78% recovery at 14d vs 52% control
- Biomechanical tensile testing
- Rat rotator cuff detachment
- Supraspinatus tendon-bone separation
- 10 μg/kg SC daily
- Tendon-bone integration strength
- 65% greater pull-out force at 28d
- Mechanical pull-out testing
- Rabbit MCL tear
- Partial ligament disruption
- Collagen organisation and tensile strength
- 82% strength recovery vs 61% control
- Histology + materials testing
- In vitro fibroblast scratch assay
- Simulated tissue gap
- 1–10 μg/mL culture medium
- Fibroblast migration rate
- 40–60% faster gap closure
- Time-lapse microscopy
- Rat patellar tendon injury
- Collagenase-induced degeneration
- Type I collagen gene expression
- 2.1-fold increase at 14d
- Real-time PCR (COL1A1)
- Professional Assessment
- BPC-157 demonstrates consistent pro-healing effects across multiple tendon injury models in rodents, with the strongest evidence in complete rupture scenarios. Dosing converges around 10 μg/kg daily regardless of administration route. The absence of primate or large-animal data and zero human trials means this remains a mechanistic research tool, not a validated therapeutic.