Source comparison
Using MK-677 for Muscle Recovery Research Evidence: Comparison
MK-677 (12.5–25 mg/day) 60–90% from baseline 22% faster strength recovery at 72h +1.5 g/day nitrogen balance Mild: transient glucose elevation, edema in 10–15% Best evidence for sustained anabolic environment; side effects manageable at research doses Exogenou
This comparison does not assign a generated winner or score.
- MK-677 (12.5–25 mg/day)
- 60–90% from baseline
- 22% faster strength recovery at 72h
- +1.5 g/day nitrogen balance
- Mild: transient glucose elevation, edema in 10–15%
- Best evidence for sustained anabolic environment; side effects manageable at research doses
- Exogenous GH (2–4 IU/day)
- Variable; peaks within 3h, clears rapidly
- Similar immediate effect but less sustained
- +1.2–1.8 g/day
- Moderate: joint pain, carpal tunnel in 20–30%; receptor downregulation risk
- Effective but requires injection timing precision; cost and regulatory barriers higher
- Placebo
- No change
- Baseline recovery timeline
- Baseline
- None
- Natural recovery timeline serves as control; no metabolic intervention
- BCAA Supplementation (10–20 g/day)
- No IGF-1 effect
- Minimal to no measurable difference
- +0.3–0.5 g/day (modest)
- Weak evidence for recovery acceleration; leucine threshold theory not supported in isolation