Source comparison
What evidence supports cyclical versus continuous MOTS-c use?
MOTS-c is run cycled, not continuously. Standard protocols run 4–6 weeks on, 2–4 weeks off. The cycling pattern preserves responsiveness and mirrors endogenous MOTS-c, which rises and falls with exercise rather than staying constantly elevated. Some practition
This comparison does not assign a generated winner or score.
- MOTS-c is run cycled, not continuously. Standard protocols run 4–6 weeks on, 2–4 weeks off. The cycling pattern preserves responsiveness and mirrors endogenous MOTS-c, which rises and falls with exercise rather than staying constantly elevated. Some practitioners use less frequent dosing (once weekly) for longer courses of up to 10 weeks as an alternative to higher-frequency short cycles.⁹