Source comparison
What's the Half-Life of PT-141?: Comparison of Melanocortin Peptides
PT-141 (Bremelanotide) 2.7 hours 2–4 hours post-injection 6–12 hours 28–30 days at 2–8°C Cyclic structure resists enzymatic breakdown; effects outlast plasma clearance due to sustained receptor occupancy Melanotan II 1.5–2 hours 3–6 hours post-injection 8–16 h
This comparison does not assign a generated winner or score.
- PT-141 (Bremelanotide)
- 2.7 hours
- 2–4 hours post-injection
- 6–12 hours
- 28–30 days at 2–8°C
- Cyclic structure resists enzymatic breakdown; effects outlast plasma clearance due to sustained receptor occupancy
- Melanotan II
- 1.5–2 hours
- 3–6 hours post-injection
- 8–16 hours
- 21–28 days at 2–8°C
- Linear structure degrades faster; longer functional duration due to higher receptor affinity and slower dissociation
- α-MSH (natural)
- <5 minutes
- N/A (endogenous)
- <30 minutes
- Not applicable
- Rapidly cleaved by neprilysin; synthetic analogs exist specifically to overcome this limitation