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Fig. 1. Mitochondrial open reading frame of the 12S ribosomal RNA type-c (MOTS-c) prevents type 1 diabetes mellitus (T1DM). T1DM is an autoimmune disease. Activated autoreactive T-cells such as Th1 cells from secondary …
Read articleMitochondrial-derived peptides (MDPs) are small peptides encoded by mitochondrial DNA that can act as signaling molecules. MOTS-c (mitochondrial open reading frame of the 12S rRNA type-c) has been reported to regulate i…
Read articleAbstract Mitochondrial ORF of the 12S rRNA Type-C (MOTS-c) is a mitochondrial-derived peptide composed of 16 amino acids encoded by the 12S rRNA region of the mitochondrial genome. The MOTS-c protein is transferred to t…
Read articleThe Discovery of MOTS-c MOTS-c was first identified in 2015 by researchers studying mitochondrial open reading frames — short protein-coding sequences in mitochondrial DNA that were previously thought to be non-function…
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