Articles and source-linked reference material filed under this topic.
Fig. 1. Mitochondrial open reading frame of the 12S ribosomal RNA type-c (MOTS-c) prevents type 1 diabetes mellitus (T1DM). T1DM is an autoimmune disease. Activated autoreactive T-cells such as Th1 cells from secondary …
Read articleMitochondrial-derived peptides (MDPs) are small peptides encoded by mitochondrial DNA that can act as signaling molecules. MOTS-c (mitochondrial open reading frame of the 12S rRNA type-c) has been reported to regulate i…
Read articleAbstract Mitochondrial ORF of the 12S rRNA Type-C (MOTS-c) is a mitochondrial-derived peptide composed of 16 amino acids encoded by the 12S rRNA region of the mitochondrial genome. The MOTS-c protein is transferred to t…
Read articlePhase 1/2 Condition N/A Treatment Autologous CD34+ HSCs transduced ex vivo with CD11B LV encoding human IDS tagged with ApoEII Clinical Study ID NCT05665166 R125432 2021-000400-38 Ages 3-22 Male MPS II is a genetic diso…
Read articleThe Discovery of MOTS-c MOTS-c was first identified in 2015 by researchers studying mitochondrial open reading frames — short protein-coding sequences in mitochondrial DNA that were previously thought to be non-function…
Read articlehttps://clinicaltrials.gov/study/NCT03575000 2025-09-22 https://clinicaltrials.gov/study/NCT03575013 2025-12-03 https://clinicaltrials.gov/study/NCT03575026 2023-09-28 https://clinicaltrials.gov/study/NCT03575039 2018-0…
Read articleMOTS-c (Mitochondrial ORF of the 12S rRNA Type-C) is a mitochondrial-derived hormone peptide discovered to be released during exercise that awakens your cells’ power generators to burn fuel more efficiently, build muscl…
Read articleApplication of peptide MOTS-c in preparation of drug for treating Parkinson's disease Download PDF Info Publication number CN113876929A CN113876929A CN202111389409.3A CN202111389409A CN113876929A CN 113876929 A CN113876…
Read articleMOTS-c for metabolic disorders: Postmenopausal women often experience hormonal changes that can lead to metabolic dysfunction and an increased risk of conditions such as obesity and impaired insulin sensitivity. A study…
Read articleBy Healing Maps Editorial Staff April 11, 2026 May 9, 2026 Peptide Articles peptide therapy peptide treatment With 0 comments Regulatory Update (April 2026): MOTS-C is one of seven peptides scheduled for FDA Pharmacy Co…
Read articleTrial Name Clinicaltrials.gov NCT Number Rapid Analysis and Response Evaluation of Combination Anti-Neoplastic Agents in Rare Tumors (RARE CANCER) Trial: RARE 1 Nilotinib and Paclitaxel NCT04449549 * 5-aza-4'-Thio-2'-De…
Read articleAbout the study The purpose of this study is to evaluate the efficacy and safety of retatrutide in participants who have obesity or overweight (J1I-MC-GZBJ master protocol) including subsets of participants who have kne…
Read articleAbstract Healthy aging can be promoted by enhanced metabolic fitness and physical capacity. Mitochondria are chief metabolic organelles with strong implications in aging that also coordinate broad physiological function…
Read article