melanotan 2 appetite: Frequently asked questions

First, verify reconstitution and storage. Temperature excursions or improper mixing can denature the peptide. If storage was correct, increase the dose to 1.5mg daily. A small percentage of subjects demonstrate reduced sensitivity to melanocortin receptor agonism due to genetic polymorphisms in MC4R. These individuals may require higher doses or may not respond at all. If no appetite suppression occurs at 1.5mg after one week, MT2 is unlikely to be effective for that subject, and alternative pathways (GLP-1, monoamine reuptake inhibitors, AMPK activators) should be explored.