Ipamorelin Dosing: 300mcg AM/PM, 5-On/2-Off (2026)
Affiliate disclosure: vendor links in this article are affiliate links — The Peptide Catalog may earn a commission if you buy through them, at no additional cost to you. Where These Numbers Come From Community Ipamorelin protocols are directly informed by clin
Affiliate disclosure: vendor links in this article are affiliate links — The Peptide Catalog may earn a commission if you buy through them, at no additional cost to you.
Where These Numbers Come From
Community Ipamorelin protocols are directly informed by clinical trial data, making the dosing rationale more evidence-based than many peptides.
The primary clinical evidence comes from a Phase II trial for postoperative ileus using 0.01-0.1 mg/kg IV with excellent tolerability (Barlind et al., 2008). Earlier research established ipamorelin's selectivity profile — significant GH release starting at low doses with minimal cortisol/prolactin elevation compared to other GHRPs (Raun et al., 1998).
The standard 300 mcg dose comes from scaling down clinical IV doses (which were much higher) and finding the optimal GH response curve for subcutaneous use. Ipamorelin's high selectivity allows effective dosing at lower amounts than other GHRPs, and its selectivity is its primary advantage — providing clean GH pulses without hormonal side effects (Johansen et al., 1999).
Stacking Protocols
CJC-1295
300 mcg AM/PM
CJC-1295 no DAC
100 mcg same syringe
Gold standard GHRH/GHRP
Sermorelin
Per protocol
All-natural GH stimulation
GHRP rotation
300 mcg (weeks 1-4)
GHRP-2 100 mcg (weeks 5-8)
—
Community rotation pattern
Ipamorelin and CJC-1295 can be mixed in the same syringe. Documented protocols maintain a fasted state for optimal GH response, and community sources describe running each peptide separately first to assess individual response before combining.
Side Effects & Safety
Injection site redness — mild, transient
Mild water retention (Raun et al., 1998 — lower GH overstimulation vs. GHRP-2)
Increased appetite — community reports describe it as milder than GHRP-6's hunger-stimulating profile (Johansen et al., 1999)
Mild headache — typically first week only
No cortisol elevation above baseline — unlike GHRP-2/GHRP-6 at equivalent doses (Raun et al., 1998)
No prolactin elevation — documented in selectivity studies vs. hexarelin (Johansen et al., 1999)
Active cancer — trials and endocrinology literature note that GH elevation could theoretically promote tumor growth; clinical trial eligibility criteria typically excluded subjects with active malignancy
mg to Units Conversion
Conversion reference (community-documented dilutions): These reflect dilutions described in community reconstitution protocols — not a prescribed dosing schedule.
On a standard 100-unit insulin syringe, each "unit" equals 0.01 mL (so 100 units = 1 mL). Once ipamorelin is reconstituted, the conversion from a target dose to syringe units depends on the chosen dilution.
The two reconstitution ratios most often described in community protocols are below.
Reconstitution A: 10 mg vial + 3 mL BAC water (3.33 mg/mL) — the standard dilution from the Quick Reference above.
150 mcg
0.045 mL
4.5 units
300 mcg
0.09 mL
9 units
450 mcg
0.135 mL
13.5 units
600 mcg
0.18 mL
18 units
Reconstitution B: 10 mg vial + 5 mL BAC water (2 mg/mL) — more BAC water for larger, easier-to-measure draws.
0.075 mL
7.5 units
0.15 mL
15 units
0.225 mL
22.5 units
0.3 mL
30 units
These conversions reflect the dilutions documented in community reconstitution protocols. They report how the math is described, not a recommended dosing schedule.
Core Supplies for This Protocol
The three essentials for running any reconstituted injectable: cold storage, accurate syringes, and metabolic tracking.
Cooluli Classic 4L Mini Fridge
Compact thermoelectric mini-fridge with heat/cool toggle. The most-mentioned dedicated peptide-storage fridge in research community sources — fits ~20 vials and runs quietly.
BD Ultra-Fine 31G 0.3cc 5/16" Insulin Syringes (Box of 90)
0.3cc 31G syringes — each gradation marks 1 unit (vs 2 units on 1cc), making sub-50-unit peptide doses accurate. BD Ultra-Fine is the most widely-cited brand in peptide community sources.
CONTOUR NEXT GEN Glucose Meter All-In-One Kit
Ascensia's CONTOUR NEXT GEN — the most clinically-validated home glucose meter. Includes 20 test strips + lancing device. Tracks the blood-sugar response GLP-1 users care about, especially during dose escalation.
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