Tesamorelin + Ipamorelin: 1mg/300mcg Blend Dosing (2026)

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Where These Numbers Come From

Tesamorelin's dosing rationale comes from the HIV lipodystrophy trials (Falutz et al., 2007; Stanley et al., 2014) where 2mg daily SC for 26 weeks produced the 15-18% visceral fat reduction. Ipamorelin dosing at 200-300 mcg comes from Bowers' dose-response work in the 1990s and subsequent phase-I/II trials showing reliable GH pulses at that range.

Trial evidence:

Tesamorelin 2mg SC daily → sustained GH/IGF-1 elevation, 15-18% visceral fat reduction over 6 months (Falutz, NEJM 2007, PMID 17699044)

Ipamorelin 200-300 mcg → peak GH 5-10x baseline within 30 minutes, no cortisol/prolactin bump (Raun, EJE 1998, PMID 9539826)

GHRH + GHRP synergy → 2-3x greater amplitude than either alone (Bowers, JCEM 1991, PMID 2004615)

Community protocols extend this evidence base with cycling patterns that weren't studied in the original trials — the 5-on/2-off rhythm and 8-week cycles are empirical community consensus, not clinically validated.

Tesamorelin + Ipamorelin vs CJC-1295 + Ipamorelin

Both are GHRH + GHRP blends. Core differences:

GHRH half-life

~25 min

~30 min

Strongest human evidence

Visceral fat (FDA-studied)

None specific (community use)

Dosing cadence

Daily PM

Daily AM/PM or 2-3x daily

Off-label fit

Body recomposition, stubborn abdominal fat

Anti-aging, sleep, recovery

Typical blend

10mg / 3mg

5mg / 5mg

Cost per mg

Higher (tesamorelin is pricier)

Lower

For visceral fat specifically, tesamorelin has the strongest case. For general anti-aging, CJC-1295 is the more-used pick. See the CJC-1295 + Ipamorelin dosing guide for the other half of this comparison.

Side Effects & Safety

Typical first-cycle side effects:

Weeks 1-2: mild water retention, vivid dreams, light head/warmth after injection

Weeks 3-4: occasional joint stiffness, improved sleep quality, slight appetite increase overnight

Weeks 5-8: adaptation phase — most side effects fade, body composition changes visible

Clinical discontinuation signals (trial-reported): Clinical participants in tesamorelin studies were discontinued upon experiencing:

Persistent headaches with visual changes (intracranial pressure marker in trial monitoring protocols)

Sustained fasting glucose elevation of ~15 mg/dL above baseline

Unusual peripheral swelling persisting beyond weeks 1-2

Carpal tunnel symptoms unresponsive to dose titration in community-reported protocols

Tesamorelin has been studied at 2mg/day for 6+ months without notable safety signals at therapeutic doses. Ipamorelin's clean profile (no cortisol/prolactin) makes the blend one of the better-tolerated GHRH+GHRP combinations.

mg to Units Conversion

On a standard 100-unit insulin syringe, each "unit" equals 0.01 mL (so 100 units = 1 mL). Because this is a pre-mixed blend, a single draw delivers both peptides together — but at different amounts, since the vial holds 10 mg tesamorelin and 3 mg ipamorelin (a fixed 10:3 ratio).

At the standard reconstitution from the Quick Reference above (10 mg / 3 mg vial + 2 mL BAC water, 5 mg/mL tesamorelin + 1.5 mg/mL ipamorelin), each draw delivers:

10 units

0.1 mL

0.5 mg

150 mcg

20 units

0.2 mL

1 mg

300 mcg

30 units

0.3 mL

1.5 mg

450 mcg

40 units

0.4 mL

2 mg

600 mcg

These conversions reflect the dilution documented in community reconstitution protocols. They report how the math is described, not a recommended dosing schedule.

Core Supplies for This Protocol

The three essentials for running any reconstituted injectable: cold storage, accurate syringes, and metabolic tracking.

Cooluli Classic 4L Mini Fridge

Compact thermoelectric mini-fridge with heat/cool toggle. The most-mentioned dedicated peptide-storage fridge in research community sources — fits ~20 vials and runs quietly.

BD Ultra-Fine 31G 0.3cc 5/16" Insulin Syringes (Box of 90)

0.3cc 31G syringes — each gradation marks 1 unit (vs 2 units on 1cc), making sub-50-unit peptide doses accurate. BD Ultra-Fine is the most widely-cited brand in peptide community sources.

CONTOUR NEXT GEN Glucose Meter All-In-One Kit

Ascensia's CONTOUR NEXT GEN — the most clinically-validated home glucose meter. Includes 20 test strips + lancing device. Tracks the blood-sugar response GLP-1 users care about, especially during dose escalation.

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