Source comparison
Best Melanotan-1 Dosage for Photoprotection: Protocol Comparison
Standard Loading (0.16mg/kg × 5 days, then maintenance every 48–72h) Daily × 5 days, then every 48–72h Fitzpatrick I–III, functional MC1R 2–3× baseline Nausea 15–20%, flushing 10% The validated clinical protocol. Use this unless individual factors warrant adju
This comparison does not assign a generated winner or score.
- Standard Loading (0.16mg/kg × 5 days, then maintenance every 48–72h)
- Daily × 5 days, then every 48–72h
- Fitzpatrick I–III, functional MC1R
- 2–3× baseline
- Nausea 15–20%, flushing 10%
- The validated clinical protocol. Use this unless individual factors warrant adjustment
- Low-Dose Titration (0.12mg/kg × 5 days, escalate if needed)
- Daily × 5 days, assess response, increase to 0.16mg/kg if minimal pigmentation by day 3
- Fitzpatrick III–IV, easy tanners
- 2–2.5× baseline
- Nausea 8–12%, flushing 5%
- Lower side effect burden with acceptable photoprotection for individuals with robust baseline eumelanin capacity
- High-Dose Override (0.20–0.22mg/kg × 5 days)
- Daily × 5 days, then every 48h
- MC1R loss-of-function variants (red hair, Type I)
- 1.5–2× baseline (receptor-limited)
- Nausea 30–40%, flushing 20–25%
- Rarely justified. Side effects increase faster than efficacy for individuals with impaired MC1R function
- Rapid Protocol (0.16mg/kg × 3 days, immediate UV exposure)
- Daily × 3 days only
- Emergency pre-exposure situations
- 1.2–1.5× baseline
- Nausea 15%, minimal efficacy
- Produces insufficient tyrosinase upregulation. Not recommended except when longer loading isn't possible