Source comparison
Best Melanotan-1 Dosage for Skin Pigmentation: Protocol Comparison
Phototype I–II (pale, red hair, MC1R variants) 0.05–0.08 Every 72–96 hours 0.02–0.025 Weekly 14–21 days Higher doses required due to reduced MC1R function. Start conservatively and titrate based on response Phototype III–IV (olive, tan easily) 0.025–0.04 0.016
This comparison does not assign a generated winner or score.
- Phototype I–II (pale, red hair, MC1R variants)
- 0.05–0.08
- Every 72–96 hours
- 0.02–0.025
- Weekly
- 14–21 days
- Higher doses required due to reduced MC1R function. Start conservatively and titrate based on response
- Phototype III–IV (olive, tan easily)
- 0.025–0.04
- 0.016–0.02
- 10–14 days
- Lower baseline doses sufficient. Excess peptide increases side effects without benefit
- Clinical afamelanotide (EPP patients)
- 0.16 (implant equivalent)
- Subcutaneous implant every 60 days
- N/A (implant)
- Every 60 days
- 7–10 days
- Pharmaceutical-grade controlled-release formulation. Not comparable to daily injections
- Off-label cosmetic (unregulated sources)
- 0.1–0.25+
- Daily or twice daily
- Highly variable
- Irregular
- Variable, often patchy
- Exceeds evidence-based range. High risk of nausea, hyperpigmentation, cardiovascular effects