Source comparison
Best Melanotan-1 Dosage Photoprotection 2026: Comparison
Clinical EPP Protocol (Scenesse Equivalent) 250–350mcg (0.16–0.25mg/kg for 70kg individual) 10–14 days before UV exposure Controlled UV at 70–80% MED, 2–3× weekly during loading 250mcg every other day or 175mcg daily throughout UV season Gold standard for phot
This comparison does not assign a generated winner or score.
- Clinical EPP Protocol (Scenesse Equivalent)
- 250–350mcg (0.16–0.25mg/kg for 70kg individual)
- 10–14 days before UV exposure
- Controlled UV at 70–80% MED, 2–3× weekly during loading
- 250mcg every other day or 175mcg daily throughout UV season
- Gold standard for photoprotection. Requires strict compliance and UV discipline
- Accelerated Loading (High-Responder Phenotype)
- 400–500mcg daily
- 7–10 days
- Natural sunlight 15–20 min daily during loading (avoid erythema)
- 250mcg 3× weekly with continued moderate UV exposure
- Higher nausea incidence; only suitable for individuals with documented MC1R sensitivity
- Conservative Protocol (Fair Skin, First-Time Use)
- 150–200mcg daily
- 14–16 days
- No UV exposure during first 10 days, then gradual introduction at 50% MED
- 150mcg 3× weekly, titrate up based on pigmentation response
- Safest for Fitzpatrick I–II skin types; lower adverse event rate but slower pigmentation
- Maintenance-Only (Post-Loading Season)
- 200–250mcg 2× weekly
- N/A (assumes prior loading phase completed)
- Intermittent UV exposure to sustain melanin turnover
- Continue 2× weekly through UV season, taper to 1× weekly in low-UV months
- Prevents rapid depigmentation; not suitable as initial protocol