Source comparison
Best Melanotan-2 Dosage for Libido: Comparison Table
0.25–0.5mg daily Mild increase in sexual desire; noticeable arousal threshold reduction after 3–5 days 3–4 hours / 6 hours Minimal. Mild flushing in 15–20% Lowest dose range tested in Phase II female arousal trials Ideal starting point for dose titration; allo
This comparison does not assign a generated winner or score.
- 0.25–0.5mg daily
- Mild increase in sexual desire; noticeable arousal threshold reduction after 3–5 days
- 3–4 hours / 6 hours
- Minimal. Mild flushing in 15–20%
- Lowest dose range tested in Phase II female arousal trials
- Ideal starting point for dose titration; allows individual response assessment without overshooting therapeutic window
- 0.5–1.0mg daily
- Moderate to significant libido enhancement; spontaneous sexual thoughts increase; improved arousal response to stimuli
- 2–3 hours / 6–8 hours
- Nausea (20–30%), facial flushing (40%), mild tanning after 7–10 days
- Most commonly used dose in published sexual dysfunction trials; highest efficacy-to-side-effect ratio
- Sweet spot for most individuals. Delivers meaningful sexual function improvement while keeping melanocortin side effects manageable
- 1.0–1.5mg daily
- Maximal sexual arousal effect; plateau in libido gains; spontaneous erections common in men
- 2–3 hours / 8 hours
- Nausea (40–50%), moderate tanning, appetite suppression, spontaneous erections (men)
- Upper therapeutic range in clinical trials; side effects begin to limit tolerability
- Therapeutic ceiling. Doses above this range produce proportionally greater side effects without additional sexual benefit
- 1.5–2.0mg daily
- No additional sexual function benefit beyond 1.0–1.5mg; side effect burden increases sharply
- 2 hours / 8–10 hours
- Nausea (50–60%), significant tanning, prolonged erections (8–12% in men), marked appetite suppression
- Tested in dose-escalation studies; higher discontinuation rates due to adverse events
- Not recommended for libido-focused protocols. Risk exceeds benefit; side effects dominate the experience
- >2.0mg daily
- No documented sexual function advantage; severe melanocortin side effects
- Variable
- Severe nausea, vomiting, priapism risk, rapid pigmentation, significant appetite loss
- Outside the range tested in formal sexual dysfunction trials
- Unwarranted. No clinical rationale for doses above 2mg when the therapeutic target is sexual function