Source comparison
Best MOTS-c Dosage AMPK Activation 2026: Protocol Comparison
Before committing to a MOTS-c protocol, understanding how different dosing strategies perform in published metabolic studies helps clarify why the 10mg three-times-weekly standard exists. 5mg 3×/week 180–220% Monday-Wednesday-Friday 12–18% reduction at week 8
This comparison does not assign a generated winner or score.
- Before committing to a MOTS-c protocol, understanding how different dosing strategies perform in published metabolic studies helps clarify why the 10mg three-times-weekly standard exists.
- 5mg 3×/week
- 180–220%
- Monday-Wednesday-Friday
- 12–18% reduction at week 8
- Minimal. Well-tolerated, lower cost
- 10mg 3×/week
- 300–380%
- 28–35% reduction at week 8
- Standard protocol. Most published data
- 15mg 3×/week
- 360–400%
- 30–38% reduction at week 8
- Diminishing returns above 10mg
- 10mg 2×/week
- 300–380% (peak only)
- Monday-Thursday
- 15–22% reduction at week 8
- 3-day gaps allow AMPK regression
- 5mg daily
- 140–180%
- 7 days/week
- 10–16% reduction at week 8
- Peak AMPK never reached. Subtherapeutic