Source comparison
Best MOTS-c Dosage Endurance 2026: Protocol Comparison
Maintenance 5mg 2x weekly 10mg/week Athletes maintaining high baseline mitochondrial density; off-season or taper phases Sustains existing oxidative capacity without metabolic overload; prevents mitochondrial regression during reduced training volume Ideal for
This comparison does not assign a generated winner or score.
- Maintenance
- 5mg
- 2x weekly
- 10mg/week
- Athletes maintaining high baseline mitochondrial density; off-season or taper phases
- Sustains existing oxidative capacity without metabolic overload; prevents mitochondrial regression during reduced training volume
- Ideal for established endurance athletes between competition blocks. Prevents decay without risking AMPK desensitisation
- Active Improvement
- 10mg
- 3x weekly
- 30mg/week
- General endurance enhancement; VO2max improvement; mitochondrial biogenesis during base-building phases
- 25–30% increase in oxidative enzyme activity; 15–20% improvement in time-to-exhaustion; enhanced fat oxidation during sub-threshold work
- Most evidence-supported tier. USC cohort data directly validates this range for measurable performance gains
- Peak Performance
- 15mg
- 45mg/week
- Competitive athletes in high-volume training blocks; racing phases requiring maximal mitochondrial output
- Maximal AMPK activation without suppression; supports training loads exceeding 15+ hours/week; accelerates recovery between sessions
- Reserve for athletes already operating at VO2max >55ml/kg/min. Lower-trained individuals see diminishing returns above 10mg