Source comparison
Best NAD+ Dosage for Anti-Aging: Delivery Route Comparison
| Delivery Method | Effective Daily Dose | Bioavailability | Plasma NAD+ Increase (%) | Cost per mg Absorbed | Professional Assessment ||—|—|—|—|—|| Sublingual NMN/NR | 250–500mg | 70–85% | 40–90% at 2 weeks | $0.15–0.30 | Optimal cost-to-efficacy ratio; most
This comparison does not assign a generated winner or score.
- | Delivery Method | Effective Daily Dose | Bioavailability | Plasma NAD+ Increase (%) | Cost per mg Absorbed | Professional Assessment ||—|—|—|—|—|| Sublingual NMN/NR | 250–500mg | 70–85% | 40–90% at 2 weeks | $0.15–0.30 | Optimal cost-to-efficacy ratio; most reliable therapeutic window for daily use || Oral Capsule NMN/NR | 500–1,000mg | 15–40% | 30–60% at 4 weeks | $0.20–0.50 | Requires higher dose due to hepatic degradation; inconsistent absorption between individuals || IV Infusion | 50–250mg per session | ~100% (direct) | 200–400% (acute spike) | $2.00–5.00 | Fastest intracellular delivery but requires clinical setting; effect duration 48–72 hours per dose || Liposomal Oral | 250–400mg | 50–60% | 35–70% at 3 weeks | $0.40–0.80 | Improved oral bioavailability vs standard capsules; useful for GI-sensitive individuals || Nicotinamide (NAM) Oral | 1,000–2,000mg | Variable (NAMPT-limited) | 0–20% at 6 weeks | $0.05–0.10 | Cheapest per mg but requires methylation cofactors; risk of meth