Source comparison
NAD+ Dosage Comparison by Form and Frequency
IV NAD+ 250–1000mg per session Weekly or twice weekly 30–60 minutes 100% (direct infusion) Highest peak concentration but shortest duration. Best for acute interventions or weekly maintenance; impractical for daily use due to cost and access Sublingual NAD+ 25
This comparison does not assign a generated winner or score.
- IV NAD+
- 250–1000mg per session
- Weekly or twice weekly
- 30–60 minutes
- 100% (direct infusion)
- Highest peak concentration but shortest duration. Best for acute interventions or weekly maintenance; impractical for daily use due to cost and access
- Sublingual NAD+
- 250–500mg
- Daily
- 60–90 minutes
- 40–60% (bypasses first-pass)
- Balanced approach for sustained elevation. Lower peaks than IV but consistent daily availability; practical for long-term protocols
- Oral NAD+
- 1000mg+
- Not applicable (mostly degraded)
- <10% (gut/liver degradation)
- Least efficient route. Requires very high doses to achieve minimal systemic NAD+; better served by precursor forms
- NMN (precursor)
- 300–1000mg
- Daily (single or split dose)
- N/A (converts intracellularly)
- 60–80% (direct cellular uptake)
- Most studied precursor. Efficient intracellular conversion with lower side-effect profile than direct NAD+; dose-response plateaus around 1000mg
- NR (precursor)
- 50–70% (requires phosphorylation)
- Effective alternative to NMN. Slightly lower conversion efficiency but well-tolerated; similar dose ceiling around 1000mg daily
- Liposomal NAD+
- 90–120 minutes (extended by liposome)
- 30–50% (lipid encapsulation)
- Improved oral bioavailability over standard oral forms but still inferior to sublingual or IV; best used when other routes are unavailable