Source comparison
Best Sermorelin Dosage Anti-Aging 2026: Protocol Comparison
Conservative 200mcg nightly 300-500mcg based on IGF-1 Baseline, Week 4, Week 8, Week 12 12 weeks on / 4 weeks off First-time users, ages 35-45, baseline IGF-1 in mid-range Standard 300mcg nightly 500-750mcg based on IGF-1 Baseline, Week 4, Week 8 16 weeks on /
This comparison does not assign a generated winner or score.
- Conservative
- 200mcg nightly
- 300-500mcg based on IGF-1
- Baseline, Week 4, Week 8, Week 12
- 12 weeks on / 4 weeks off
- First-time users, ages 35-45, baseline IGF-1 in mid-range
- Standard
- 300mcg nightly
- 500-750mcg based on IGF-1
- Baseline, Week 4, Week 8
- 16 weeks on / 4 weeks off
- Ages 45-60, baseline IGF-1 in lower quartile
- Aggressive
- 500mcg nightly
- 750-1000mcg based on IGF-1
- Baseline, Week 4, Week 6, Week 8
- 12 weeks on / 6 weeks off
- Ages 60+, significantly suppressed baseline IGF-1, under medical supervision
- Maintenance
- 300-500mcg nightly (fixed)
- No titration
- Every 12 weeks
- Continuous with periodic 2-week breaks every 6 months
- Patients who've completed initial titration and reached stable IGF-1 targets
- Professional Assessment
- All protocols require baseline lab work (IGF-1, fasting glucose, thyroid panel) before initiation. Doses above 1000mcg nightly rarely produce additional benefit and increase metabolic side effect risk. Individual response variability means these are starting frameworks—adjust based on biomarker feedback, not subjective symptoms alone.