Source comparison
Best Sermorelin Dosage for Bone Density 2026: Protocol Comparison
Conservative 200 mcg nightly Increase by 50 mcg every 4 weeks if IGF-1 rise < 15% 150–200 ng/mL 1.5–2.5% lumbar spine Best for adults over 60 or those with multiple comorbidities. Minimises risk of supraphysiological IGF-1 while still supporting bone formation
This comparison does not assign a generated winner or score.
- Conservative
- 200 mcg nightly
- Increase by 50 mcg every 4 weeks if IGF-1 rise < 15%
- 150–200 ng/mL
- 1.5–2.5% lumbar spine
- Best for adults over 60 or those with multiple comorbidities. Minimises risk of supraphysiological IGF-1 while still supporting bone formation
- Standard
- 300 mcg nightly
- Adjust by ±50 mcg at week 8 based on IGF-1 response
- 180–250 ng/mL
- 2.5–4.0% lumbar spine
- Appropriate for most adults 40–65 with baseline IGF-1 < 150 ng/mL. Balances efficacy and safety
- Aggressive
- 400–500 mcg nightly
- Fixed dose with IGF-1 monitoring every 6 weeks
- 200–280 ng/mL
- 3.5–5.0% lumbar spine
- Reserved for adults with severe osteopenia (T-score < -2.0) and confirmed low baseline IGF-1. Requires close monitoring for insulin resistance
- Pulsatile
- 250 mcg 5 nights/week
- 2 nights off per week to prevent receptor desensitisation
- 160–220 ng/mL
- 2.0–3.5% lumbar spine
- Mimics natural GH pulsatility. May preserve long-term receptor sensitivity but lacks robust clinical trial data