Source comparison
BPC-157 IBS Mechanism: Research Comparison
Rat colitis (TNBS-induced) 10 µg/kg IP daily × 7 days Mucosal VEGF expression, tight junction protein levels 60% faster mucosal healing; 2.8× VEGFR2 expression Acute injury model. Doesn't replicate chronic low-grade IBS pathology Mouse post-infectious IBS (T.
This comparison does not assign a generated winner or score.
- Rat colitis (TNBS-induced)
- 10 µg/kg IP daily × 7 days
- Mucosal VEGF expression, tight junction protein levels
- 60% faster mucosal healing; 2.8× VEGFR2 expression
- Acute injury model. Doesn't replicate chronic low-grade IBS pathology
- Mouse post-infectious IBS (T. spiralis)
- 10 µg/kg IP daily × 14 days
- Visceral pain threshold, mast cell density
- 35% reduction in abdominal withdrawal reflex; 42% fewer mucosal mast cells
- Single pathogen model; human IBS is multifactorial
- Human colonic organoid culture
- 1 µg/mL × 48 hours
- Tight junction reassembly (ZO-1, occludin), barrier resistance
- 3.2× faster wound closure; increased transepithelial electrical resistance (TEER)
- In vitro only. Pharmacokinetics and systemic absorption not modelled
- Rat NSAID gastropathy
- 10 µg/kg IP daily × 3 days
- eNOS pathway modulation, angiogenesis markers
- 55% reduction in gastric lesion area; preserved NO bioavailability
- Stomach model, not intestinal; short treatment duration