Source comparison
CJC-1295 No DAC & Ipamorelin: Protocol Comparison
GH Pulse Frequency 1 amplified pulse per 24hr 2 amplified pulses per 24hr Sustained elevation (non-pulsatile) Natural pulsatility preserved Twice-daily pulsed mimics natural secretion; continuous blunts receptor sensitivity Cortisol Impact Minimal (dosed at co
This comparison does not assign a generated winner or score.
- GH Pulse Frequency
- 1 amplified pulse per 24hr
- 2 amplified pulses per 24hr
- Sustained elevation (non-pulsatile)
- Natural pulsatility preserved
- Twice-daily pulsed mimics natural secretion; continuous blunts receptor sensitivity
- Cortisol Impact
- Minimal (dosed at cortisol nadir)
- Low if AM dose is post-workout
- Moderate (cortisol/prolactin elevation with high-frequency Ipamorelin)
- Minimal (washout resets HPA axis)
- Bedtime-only dosing avoids cortisol interference entirely
- Pituitary Sensitivity
- Maintained with 4wk washouts
- Progressively declines after 16–20 weeks
- Fully restored during washout
- Cycling is non-negotiable for long-term efficacy
- IGF-1 Response
- 20–30% increase at week 8
- 30–40% increase at week 8
- Peaks at week 8, plateaus by week 16
- Consistent 20–40% increase across multiple cycles
- Twice-daily pulsed produces highest sustained IGF-1 without desensitization
- Optimal Use Case
- Researchers prioritizing sleep/recovery
- Researchers training 5–6 days/week
- Not recommended (diminishing returns)
- Anti-aging protocols requiring long-term use
- Pulsed cycling with twice-daily dosing is the gold standard for multi-year protocols