Source comparison
Comparison Table: Kisspeptin-54 vs Kisspeptin-10
Amino Acid Length 54 amino acids 10 amino acids (C-terminal fragment) Kisspeptin-10 requires significantly less mass per dose Molecular Weight ~6 kDa ~1.3 kDa Smaller size allows faster tissue diffusion and BBB crossing Receptor Affinity (KISS1R) Identical Bot
This comparison does not assign a generated winner or score.
- Amino Acid Length
- 54 amino acids
- 10 amino acids (C-terminal fragment)
- Kisspeptin-10 requires significantly less mass per dose
- Molecular Weight
- ~6 kDa
- ~1.3 kDa
- Smaller size allows faster tissue diffusion and BBB crossing
- Receptor Affinity (KISS1R)
- Identical
- Both produce the same maximal GnRH/LH response at equimolar doses
- Plasma Half-Life (IV)
- 27–32 minutes
- 4–6 minutes
- Kisspeptin-10 clears faster. Preferable for acute-response studies
- Proteolytic Stability
- Susceptible to N-terminal cleavage
- Resistant (no N-terminal tail to cleave)
- Kisspeptin-10 retains activity longer in protease-rich environments
- Time to Peak LH (subcutaneous)
- 45–60 minutes
- 20–30 minutes
- Kisspeptin-10 produces faster hormonal response
- Typical Research Dose (human)
- 0.3–1.0 nmol/kg IV
- 1.0–4.0 nmol/kg IV
- Higher doses needed for kisspeptin-10 due to rapid clearance
- Primary Use Case
- Sustained or repeated-dose studies
- Acute challenge tests, pharmacokinetic studies
- Choose based on whether you need prolonged vs transient receptor activation
- Storage Stability (lyophilised)
- Stable at −20°C for 24+ months
- Both degrade rapidly once reconstituted. Use within 14 days at 2–8°C
- Bottom Line
- Full-length endogenous form with slower kinetics
- Active fragment with faster onset and shorter duration
- Functionally equivalent at receptor level; selection depends on experimental timing