Source comparison
Kisspeptin vs Kisspeptin-10: Structural Comparison
Amino Acid Length 54 residues (full-length metastin) 10 residues (C-terminal fragment) Kisspeptin-10 is easier to synthesize with fewer impurities Molecular Weight ~5.9 kDa ~1.3 kDa Mass-to-molar conversion required when comparing doses Plasma Half-Life (roden
This comparison does not assign a generated winner or score.
- Amino Acid Length
- 54 residues (full-length metastin)
- 10 residues (C-terminal fragment)
- Kisspeptin-10 is easier to synthesize with fewer impurities
- Molecular Weight
- ~5.9 kDa
- ~1.3 kDa
- Mass-to-molar conversion required when comparing doses
- Plasma Half-Life (rodent models)
- 90–120 minutes
- 27–32 minutes
- Kisspeptin-10 requires 3–4× more frequent dosing for sustained effect
- KISS1R Receptor Affinity
- EC₅₀ 0.5–2 nM
- Functionally equivalent at the receptor level
- Metabolic Stability
- Protected N-terminus resists peptidases
- Rapidly cleaved by aminopeptidases
- Kisspeptin-54 preferred for chronic infusion studies
- Typical Research Dose (rodent)
- 1–10 nmol/kg i.v. or s.c.
- 1.2–15 nmol/kg i.v. or s.c.
- Kisspeptin-10 often requires 20–30% higher molar dose
- Primary Use Context
- Sustained GnRH stimulation, long-term reproductive studies
- Acute LH release assays, receptor pharmacology, pulse studies
- Bottom Line: Choose kisspeptin-10 for rapid-onset single-dose studies; kisspeptin-54 for multi-day protocols