Source comparison
Half-Life Comparison Across IGF-1 Analogs
Native IGF-1 (free) ~10–20 minutes Rapid IGFBP sequestration Native IGF-1 (IGFBP-3 bound) ~12–15 hours Ternary complex formation; biologically inactive form IGF-1 DES ~20–30 minutes Partially reduced IGFBP binding; still cleared relatively rapidly IGF-1 LR3 ~2
This comparison does not assign a generated winner or score.
- Native IGF-1 (free)
- ~10–20 minutes
- Rapid IGFBP sequestration
- Native IGF-1 (IGFBP-3 bound)
- ~12–15 hours
- Ternary complex formation; biologically inactive form
- IGF-1 DES
- ~20–30 minutes
- Partially reduced IGFBP binding; still cleared relatively rapidly
- IGF-1 LR3
- ~20–30 hours
- ~1,000x reduced IGFBP binding; minimal ternary complex formation
- Note that while IGFBP-3-bound native IGF-1 has a long apparent half-life, this bound fraction is largely biologically inactive. The relevant comparison for receptor engagement is the free-form half-life.