Source comparison
How to Use Peptides for Bodybuilding: Compound Comparison
Before selecting a peptide protocol, understanding the functional differences between compound classes prevents mismatched expectations. This table compares the most commonly researched peptides by mechanism, dosing frequency, and practical administration cons
This comparison does not assign a generated winner or score.
- Before selecting a peptide protocol, understanding the functional differences between compound classes prevents mismatched expectations. This table compares the most commonly researched peptides by mechanism, dosing frequency, and practical administration constraints.
- Ipamorelin
- Ghrelin receptor agonist (GHRP). Triggers GH pulse without cortisol/prolactin elevation
- 200–300mcg per injection
- 2–3 times daily (fasting, post-workout, pre-bed)
- ~2 hours
- Cleanest GHRP profile for sustained use. No desensitization risk, pairs well with CJC-1295
- CJC-1295 (with DAC)
- GHRH analog. Extends GH pulse duration via drug affinity complex
- 1–2mg per injection
- Once or twice weekly
- 6–8 days
- Best for convenience. Weekly dosing maintains stable IGF-1 elevation, but cannot pulse GH on-demand
- CJC-1295 (no DAC / Mod GRF 1-29)
- GHRH analog. Amplifies GH release when stacked with GHRPs
- 100–200mcg per injection
- 2–3 times daily
- ~30 minutes
- Requires frequent dosing but allows precise control. Ideal for stacking with ipamorelin
- Hexarelin
- Potent ghrelin receptor agonist. Strongest GH pulse, also elevates cortisol/prolactin at high doses
- 2 times daily, cycled (4–6 weeks on, 4 weeks off)
- ~70 minutes
- Most potent GHRP but desensitizes receptors. Cycle required, not suitable for continuous use
- MK-677 (Ibutamoren)
- Oral ghrelin mimetic. Non-peptide GH secretagogue
- 10–25mg once daily
- Once daily (oral, typically evening)
- ~24 hours
- Only oral option. Sustained GH/IGF-1 elevation but also increases appetite and fasting glucose