Source comparison
IGF-1 LR3 Benefits: Comparison to HGH and Standard IGF-1
Half-life 20-30 hours 12-15 minutes GH: 3-5 hours IGFBP binding Minimal (evades binding) 95%+ bound (inactive) N/A (produces IGF-1 indirectly) Bioactive fraction ~100% ~5% free Indirect via liver IGF-1 Satellite cell activation Direct, potent Direct but brief
This comparison does not assign a generated winner or score.
- Half-life
- 20-30 hours
- 12-15 minutes
- GH: 3-5 hours
- IGFBP binding
- Minimal (evades binding)
- 95%+ bound (inactive)
- N/A (produces IGF-1 indirectly)
- Bioactive fraction
- ~100%
- ~5% free
- Indirect via liver IGF-1
- Satellite cell activation
- Direct, potent
- Direct but brief
- Indirect via IGF-1
- Dosing frequency
- Once daily
- Multiple daily
- 1-3x daily (secretagogues)
- Muscle specificity
- High (direct receptor activation)
- Moderate
- Systemic
- PSPeptides price
- Buy IGF-1 LR3
- —
- CJC/Ipa $65.99, Tesamorelin $59.99
- The key distinction: HGH and GH secretagogues — CJC-1295/Ipamorelin ($65.99), Tesamorelin (from $59.99), Sermorelin (from $44.99) at PSPeptides — stimulate the liver to produce IGF-1 indirectly. The LR3 analog bypasses this intermediary step entirely, delivering the end-effector molecule directly to IGF-1 receptors at maximum potency. For researchers wanting both upstream GH benefits (sleep, recovery, fat metabolism) AND the muscle-specific downstream signal, stacking GH secretagogues with IGF-1 LR3 provides both pathways simultaneously. The CJC-1295/Ipamorelin guide covers GH secretagogue mechanisms in detail.