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Therapeutic Interest Versus Bodybuilding and Performance Claims

Searches for IGF-1 LR3 often focus on muscle growth, muscle growth and recovery, body composition, or performance. The biological interest comes from the role of IGF-1 signaling in skeletal muscle protein synthesis, anabolism, and cell-growth pathways [12] [13

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  • Searches for IGF-1 LR3 often focus on muscle growth, muscle growth and recovery, body composition, or performance. The biological interest comes from the role of IGF-1 signaling in skeletal muscle protein synthesis, anabolism, and cell-growth pathways [12] [13].
  • That does not make performance claims clinically proven. IGF-1 and its analogues are also prohibited in sport under WADA rules, which reflects anti-doping policy and safety concerns rather than evidence of safe or effective personal use [19].
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Comparison

IGF-1 LR3 versus IGF-1 DES

Another common IGF-1 variant, IGF-1 DES (Des 1-3), takes the opposite approach to modification. Instead of adding amino acids, DES removes the first three from the N-terminus, cre…

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