Source comparison
IGF-1 LR3 Side Effects: Study Comparison
Hypoglycemia 25–35 mg/dL glucose drop in rats (Endocrinology 2004) 0.5–1.5 mg/kg daily Resolves 24–48h post-dose Anecdotal reports only. No clinical trials Insulin receptor desensitisation 40–50% receptor downregulation in hepatocytes after 6 weeks (JBC 2011)
This comparison does not assign a generated winner or score.
- Hypoglycemia
- 25–35 mg/dL glucose drop in rats (Endocrinology 2004)
- 0.5–1.5 mg/kg daily
- Resolves 24–48h post-dose
- Anecdotal reports only. No clinical trials
- Insulin receptor desensitisation
- 40–50% receptor downregulation in hepatocytes after 6 weeks (JBC 2011)
- 1 mg/kg daily for ≥6 weeks
- Partial recovery after 4-week washout
- Not measured in humans
- Cardiac hypertrophy
- 18% increase in left ventricular mass in rats (GH&IGF 2009)
- 1 mg/kg daily for 8 weeks
- No recovery observed in 4-week follow-up
- Hepatomegaly
- 22% increase in liver weight relative to body weight (GH&IGF 2009)
- Persistent after 4-week washout
- Joint pain / acromegaly-like effects
- Not modeled in animal studies. Cartilage overgrowth not measured
- N/A
- Unknown
- Frequent anecdotal reports in user communities