Source comparison
Melanotan-2 Dosing: Research Protocol Comparison
Initial Loading (Days 1–7) 250mcg Daily (evening) None on Days 1–2; 5–8 min UV-A on Days 3, 5, 7 Visible baseline tan by Day 5–7 Slow titration prevents nausea and establishes even MC1R activation across all melanocyte populations Late Loading (Days 8–14) 250–
This comparison does not assign a generated winner or score.
- Initial Loading (Days 1–7)
- 250mcg
- Daily (evening)
- None on Days 1–2; 5–8 min UV-A on Days 3, 5, 7
- Visible baseline tan by Day 5–7
- Slow titration prevents nausea and establishes even MC1R activation across all melanocyte populations
- Late Loading (Days 8–14)
- 250–500mcg
- Daily
- 10–12 min UV-A every other day
- Deepening pigmentation, 80% of final result visible
- Gradual UV increase matches rising tyrosinase activity. Rushing this phase causes patchy results
- Maintenance (Week 3+)
- 500mcg
- Every 72–96 hours
- 15–20 min UV-A once weekly
- Stable pigmentation, minor deepening through Week 6
- Longer intervals prevent receptor desensitisation; weekly UV sustains melanin without photoaging risk
- Off-Cycle Recovery
- None
- N/A
- Minimal UV exposure
- Gradual fade over 4–8 weeks
- 4–6 week breaks allow receptor resensitisation and prevent tolerance build-up