Source comparison
MOTS-c Dosage Protocols: Frequency vs Magnitude Comparison
5mg 3x/week 15mg 23% (USC study) Consistent pulsatile. Peaks every 48–72 hours High. Fits MWF schedule Optimal for most users. Balances efficacy and convenience 10mg 2x/week 20mg 19% (USC study) Moderate pulsatile. 72–96 hour gaps Moderate. Requires precise sp
This comparison does not assign a generated winner or score.
- 5mg 3x/week
- 15mg
- 23% (USC study)
- Consistent pulsatile. Peaks every 48–72 hours
- High. Fits MWF schedule
- Optimal for most users. Balances efficacy and convenience
- 10mg 2x/week
- 20mg
- 19% (USC study)
- Moderate pulsatile. 72–96 hour gaps
- Moderate. Requires precise spacing
- Good for restoration protocols or higher body weight
- 15mg 1x/week
- 14% (USC study)
- Single peak, 6-day trough
- Very high. Once weekly
- Suboptimal. Long gaps allow AMPK signaling to fully return to baseline
- 2.5mg daily
- 17.5mg
- Not clinically tested in humans
- Near-constant activation
- Low. Daily injections impractical
- Theoretically ideal but impractical outside research settings
- 7.5mg 2x/week
- Estimated 17–20% (interpolated)
- Moderate pulsatile
- High. Twice weekly dosing sustainable
- Strong middle-ground option for metabolically healthy users