Source comparison
Sermorelin for Men: Peptide Comparison
Sermorelin GHRH analog. Stimulates endogenous GH pulse 8–12 minutes 200–500mcg before sleep Restores natural GH secretion rhythm without pituitary suppression Preserves GHRH receptor sensitivity Exogenous HGH Direct somatropin replacement 2.5–3 hours 2–4 IU da
This comparison does not assign a generated winner or score.
- Sermorelin
- GHRH analog. Stimulates endogenous GH pulse
- 8–12 minutes
- 200–500mcg before sleep
- Restores natural GH secretion rhythm without pituitary suppression
- Preserves GHRH receptor sensitivity
- Exogenous HGH
- Direct somatropin replacement
- 2.5–3 hours
- 2–4 IU daily
- Immediate IGF-1 elevation, rapid anabolic response
- Suppresses endogenous pituitary GH output after 8–12 weeks
- CJC-1295 (DAC)
- Long-acting GHRH analog with drug affinity complex
- 6–8 days
- 2mg weekly
- Sustained GH elevation without daily dosing
- Chronic receptor activation. May reduce pulsatility over time
- Ipamorelin
- Ghrelin mimetic. Stimulates GH release via different pathway
- 2 hours
- 200–300mcg 2–3x daily
- Amplifies GH pulses when stacked with GHRH analogs, minimal cortisol spike
- Complements GHRH without cross-desensitization
- MK-677 (oral)
- Orally bioavailable ghrelin receptor agonist
- 24 hours
- 10–25mg before sleep
- Convenient oral dosing, sustained GH and IGF-1 elevation
- May increase appetite and insulin resistance at higher doses