Source comparison
Sermorelin vs Ipamorelin
Sermorelin and ipamorelin work through entirely different receptors. Sermorelin activates the GHRH receptor. Ipamorelin activates the ghrelin receptor (GHS-R). The GH pulse from each is additive when combined because they trigger release through separate intra
This comparison does not assign a generated winner or score.
- Sermorelin and ipamorelin work through entirely different receptors. Sermorelin activates the GHRH receptor. Ipamorelin activates the ghrelin receptor (GHS-R). The GH pulse from each is additive when combined because they trigger release through separate intracellular pathways.
- Ipamorelin has two advantages for fat loss: it does not significantly raise cortisol or prolactin (unlike other GHRPs such as GHRP-6 or GHRP-2), and it has a longer half-life of approximately 2 hours, producing a more sustained GH elevation per injection.
- The sermorelin + ipamorelin stack (300 mcg + 200-300 mcg before bed) is widely considered the gold standard for GH optimization in the peptide community. The combination produces GH pulses 3-5 times larger than either peptide alone, translating to meaningfully greater lipolysis. Use the peptide cost calculator to compare the expense of single vs stacked protocols.