Source comparison
TB-500 Research Renal Considerations: Dosing Comparison
Normal (≥90 mL/min/1.73m²) 5–10 mg/kg No adjustment Every 3–4 days Full clearance capacity Mild Impairment (60–89) 4–8 mg/kg Every 4–5 days 15–20% clearance reduction Moderate Impairment (30–59) 3–5 mg/kg Every 5–7 days 40–55% clearance reduction Severe Impair
This comparison does not assign a generated winner or score.
- Normal (≥90 mL/min/1.73m²)
- 5–10 mg/kg
- No adjustment
- Every 3–4 days
- Full clearance capacity
- Mild Impairment (60–89)
- 4–8 mg/kg
- Every 4–5 days
- 15–20% clearance reduction
- Moderate Impairment (30–59)
- 3–5 mg/kg
- Every 5–7 days
- 40–55% clearance reduction
- Severe Impairment (<30)
- 2–4 mg/kg
- Every 7–10 days
- >60% clearance reduction
- Dialysis-Dependent
- 2–3 mg/kg
- Post-dialysis, every 7–10 days
- Minimal dialytic clearance