Source comparison
Tesamorelin Protocol: Clinical Comparison
Tesamorelin GHRH analogue—stimulates pituitary GH release while preserving feedback loops 2mg SC daily (evening) 15–22% +60–90 ng/mL (moderate, physiological) Low—transient hyperglycemia in first month, improves with VAT reduction Gold standard for visceral fa
This comparison does not assign a generated winner or score.
- Tesamorelin
- GHRH analogue—stimulates pituitary GH release while preserving feedback loops
- 2mg SC daily (evening)
- 15–22%
- +60–90 ng/mL (moderate, physiological)
- Low—transient hyperglycemia in first month, improves with VAT reduction
- Gold standard for visceral fat targeting in metabolic optimization; requires daily injections but avoids supraphysiological GH spikes
- Ipamorelin
- Ghrelin mimetic—stimulates GH via ghrelin receptor, no cortisol/prolactin elevation
- 200–300 mcg SC 2–3× daily
- 8–12% (less selective for VAT)
- +40–60 ng/mL (lower peak)
- Very low
- Better tolerated but less effective for pure VAT reduction; useful when tesamorelin causes persistent injection site reactions
- CJC-1295 (with DAC)
- Long-acting GHRH analogue—extends GH elevation for 7–10 days per injection
- 2mg SC weekly
- 10–15% (comparable to tesamorelin at 6 months)
- +70–110 ng/mL (higher, sustained)
- Moderate—prolonged IGF-1 elevation increases insulin resistance risk
- Less physiological pulsatility; convenient dosing but higher risk of IGF-1 overshooting therapeutic range
- Exogenous GH (somatropin)
- Direct GH replacement—bypasses endogenous regulation entirely
- 0.2–0.4 IU SC daily
- 18–25% (most potent)
- +120–200 ng/mL (supraphysiological)
- High—dose-dependent insulin resistance, fluid retention, joint pain
- Most effective for VAT reduction but least physiological; reserved for confirmed GH deficiency (IGF-1 <100 ng/mL)
- Sermorelin
- Short-acting GHRH analogue—stimulates pituitary but clears rapidly
- 200–500 mcg SC daily
- 6–10% (weakest VAT effect)
- +30–50 ng/mL (minimal)
- Mildest option; used in patients with mild metabolic dysfunction or as adjunct to other interventions