Source comparison
Best NAD+ Dosage Addiction Recovery 2026: Protocol Comparison
Springfield 10-Day Protocol 1000mg IV daily × 10 days 500mg IV every 14 days × 12 weeks 13 weeks Case series (n=47) showed 79% completion rate, 21% relapse at 90 days Most aggressive loading. Best for severe alcohol dependence or polysubstance use UC San Diego
This comparison does not assign a generated winner or score.
- Springfield 10-Day Protocol
- 1000mg IV daily × 10 days
- 500mg IV every 14 days × 12 weeks
- 13 weeks
- Case series (n=47) showed 79% completion rate, 21% relapse at 90 days
- Most aggressive loading. Best for severe alcohol dependence or polysubstance use
- UC San Diego Moderate Protocol
- 750mg IV daily × 10 days
- 250mg IV weekly × 8 weeks
- 10 weeks
- RCT (n=94) showed 18% relapse vs 47% control at 90 days
- Balanced efficacy/tolerability. Validated in peer-reviewed trial
- Scripps Extended Protocol
- 500mg IV daily × 14 days
- 500mg IV every 7 days × 12 weeks
- 16 weeks
- Observational study (n=68) showed sustained NAD+ elevation at 90 days
- Longer acute phase, higher maintenance frequency. Best for opioid dependence
- Outpatient Maintenance-Only
- None (post-detox entry)
- 500mg IV every 10 days × 12 weeks
- 12 weeks
- Retrospective analysis showed 34% relapse vs 47% standard care
- Lower efficacy than acute loading protocols. Use only if acute phase completed elsewhere