Source comparison
Best NAD+ Dosage Chronic Fatigue 2026: Protocol Comparison
NR 500mg twice daily 1000mg NR Week 1: 250mg once daily; Week 2–3: 250mg twice daily; Week 4+: 500mg twice daily 4–6 hours Moderate. 20–25% experience transient nausea during titration $80–120 Strong. Multiple RCTs, dose-ranging studies up to 2000mg Gold stand
This comparison does not assign a generated winner or score.
- NR 500mg twice daily
- 1000mg NR
- Week 1: 250mg once daily; Week 2–3: 250mg twice daily; Week 4+: 500mg twice daily
- 4–6 hours
- Moderate. 20–25% experience transient nausea during titration
- $80–120
- Strong. Multiple RCTs, dose-ranging studies up to 2000mg
- Gold standard for chronic fatigue; most published human safety data
- NMN 250–500mg once daily
- 250–500mg NMN
- Week 1: 125–250mg once daily; Week 2–3: 250mg once daily; Week 4+: 500mg if tolerated
- 3.5–5 hours
- Moderate-high. Sublingual reduces GI effects vs capsules
- $90–140
- Moderate. Fewer human RCTs than NR, strong preclinical mechanistic data
- Comparable efficacy to NR; slightly faster plasma peak, less dosing data
- Nicotinamide (NAM) 500mg twice daily
- 1000mg NAM
- 500mg twice daily from start. No titration needed
- 2–3 hours
- High. Minimal GI effects
- $15–30
- Weak for fatigue. No controlled trials in CFS/ME populations
- Not recommended. Inhibits sirtuins at high doses, negating NAD+ benefits
- IV NAD+ 250–500mg weekly
- 250–500mg NAD+
- Single weekly infusion over 2–4 hours
- Peak during infusion, undetectable by 6 hours
- Low GI effects, moderate infusion site discomfort
- $300–600
- Very weak. Case reports only, no controlled trials
- Expensive with no evidence of superiority over oral precursors
- Combination NR + pterostilbene
- 500mg NR + 50–100mg pterostilbine daily
- Week 1: 250mg NR only; Week 2+: add pterostilbene
- Moderate
- $100–160
- Moderate. Pterostilbene activates SIRT1, synergistic in animal models
- Emerging approach; pterostilbene may enhance NAD+ utilization, but human data limited