Source comparison
Best NAD+ Dosage for DNA Repair: Form Comparison
NMN (oral) 250–500mg daily Moderate (15–30% systemic) 30–60 minutes 8-OHdG reduced 18–25%, gamma-H2AX foci reduced 20–34% in split-dose trials Most studied precursor with consistent human trial data; split dosing required for circadian alignment NR (oral) 300–
This comparison does not assign a generated winner or score.
- NMN (oral)
- 250–500mg daily
- Moderate (15–30% systemic)
- 30–60 minutes
- 8-OHdG reduced 18–25%, gamma-H2AX foci reduced 20–34% in split-dose trials
- Most studied precursor with consistent human trial data; split dosing required for circadian alignment
- NR (oral)
- 300–600mg daily
- Moderate (20–35% systemic)
- 45–90 minutes
- Similar to NMN in head-to-head trials; 8-OHdG reduced 15–22%
- Slightly higher first-pass stability than NMN but requires conversion through NMN intermediate. No clear advantage
- NAD+ IV infusion
- 250–500mg per session
- High (near 100%)
- Immediate
- Acute elevation in PARP activity within 2 hours; sustained effects require weekly administration
- Fastest plasma elevation but impractical for daily use; best for acute intervention or clinical settings
- Liposomal NAD+
- 100–250mg daily
- Moderate-High (40–60% estimated)
- 20–40 minutes
- Limited published data; anecdotal reports suggest efficacy between oral NMN and IV
- Emerging delivery method; phospholipid encapsulation bypasses some gut degradation but lacks long-term trial data
- Sublingual NMN
- 125–250mg daily
- Moderate-High (30–50% estimated)
- 15–30 minutes
- Comparable to oral NMN in small trials; buccal absorption avoids hepatic first-pass
- Faster peak but shorter half-life; may require more frequent dosing than oral