Source comparison
Biohackers NAD+ Protocol: Dosing Comparison
NMN 500–1000mg daily, split AM/PM Fasted morning + mid-afternoon Bypasses NRK enzyme. Directly enters NAMPT pathway as mononucleotide Most biohackers choose NMN for speed of conversion; clinical data supports 900mg+ as effective threshold NR 300–600mg daily, s
This comparison does not assign a generated winner or score.
- NMN
- 500–1000mg daily, split AM/PM
- Fasted morning + mid-afternoon
- Bypasses NRK enzyme. Directly enters NAMPT pathway as mononucleotide
- Most biohackers choose NMN for speed of conversion; clinical data supports 900mg+ as effective threshold
- NR
- 300–600mg daily, split AM/PM
- Requires phosphorylation by NRK before NAMPT can convert to NAD+
- Slightly slower kinetics than NMN but more shelf-stable; effective when dosed consistently
- Niacin (Vitamin B3)
- 50–100mg daily, single dose
- With food to minimize flushing
- Enters NAMPT pathway after conversion to nicotinamide; causes vasodilation
- Cheapest option but flushing limits tolerability; not preferred in biohackers nad+ protocol
- NAD+ IV infusion
- 250–500mg per session, weekly
- Clinical administration
- Bypasses oral absorption. Direct systemic NAD+ elevation
- Expensive ($400–800/session); effect duration is 3–5 days before hepatic clearance
- Liposomal NMN
- 250–500mg daily, single AM dose
- Fasted morning
- Phospholipid encapsulation improves GI absorption and cellular uptake
- Emerging option; limited clinical data but anecdotal reports suggest lower doses achieve similar effect