Source comparison
Longevity Researchers NAD+ Protocol: Implementation Comparison
NAD+ Precursor NMN 500-1000mg daily NR 300mg daily (Basis formulation) NR 500mg daily NMN 500mg daily NR 250-500mg offers best evidence-to-cost ratio for most users; NMN viable at equivalent doses Methylation Support TMG 1g daily Not included in Basis TMG 500-
This comparison does not assign a generated winner or score.
- NAD+ Precursor
- NMN 500-1000mg daily
- NR 300mg daily (Basis formulation)
- NR 500mg daily
- NMN 500mg daily
- NR 250-500mg offers best evidence-to-cost ratio for most users; NMN viable at equivalent doses
- Methylation Support
- TMG 1g daily
- Not included in Basis
- TMG 500-1000mg recommended separately
- TMG 500mg daily
- 1-2g TMG is non-negotiable at doses >250mg NAD+ precursor to prevent homocysteine elevation
- Dosing Timing
- Morning, fasted state
- Morning with or without food
- Morning preferred
- Morning, pre-workout
- Morning administration during NAMPT peak (7-9 AM) maximises salvage pathway efficiency
- Cycling Pattern
- Continuous daily use
- Not specified
- 5 days on, 2 days off
- Monthly 5-7 day breaks prevent NAMPT enzyme downregulation; weekly cycling lacks evidence
- Additional Cofactors
- Resveratrol 1g, metformin 500-1000mg
- Pterostilbene 50mg (Basis formulation)
- None specified
- None beyond methylation
- Resveratrol/pterostilbene amplify sirtuin activity but bioavailability limits impact; metformin acts independently
- Published Human Data
- Preclinical primarily; awaiting human NMN trials
- Phase 2 RCT showing 40% NAD+ increase
- Multiple RCTs with NR at 500-1000mg
- Systematic review-based
- Brenner's NR trials offer most robust human pharmacokinetic data; Sinclair's work remains largely preclinical for NMN