Source comparison
Men 55+ Longevity NAD+ Protocol: Clinical vs Research-Grade Implementation
Nicotinamide Riboside (NR) 300mg daily 500–1000mg daily Bypasses NAMPT, converts to NAD+ via NRK1/NRK2 Higher doses show sustained elevation; well-tolerated long-term Nicotinamide Mononucleotide (NMN) 250mg daily Direct NAD+ precursor; Slc12a8-mediated transpo
This comparison does not assign a generated winner or score.
- Nicotinamide Riboside (NR)
- 300mg daily
- 500–1000mg daily
- Bypasses NAMPT, converts to NAD+ via NRK1/NRK2
- Higher doses show sustained elevation; well-tolerated long-term
- Nicotinamide Mononucleotide (NMN)
- 250mg daily
- Direct NAD+ precursor; Slc12a8-mediated transport
- Better hepatic uptake; optimal for insulin resistance
- Resveratrol
- 150mg daily
- 250–500mg daily
- SIRT1 activator; lowers Km for NAD+
- Synergistic with NR/NMN; enhanced at higher doses
- Pterostilbene
- 50mg daily
- 100–150mg daily
- Methylated resveratrol analogue; better bioavailability
- More lipophilic than resveratrol; crosses BBB efficiently
- Quercetin
- 500mg daily
- 1000mg daily split
- Senolytic; reduces CD38-driven NAD+ degradation
- Requires consistent dosing; fat-soluble absorption
- Timing
- Morning fasted
- Split AM/PM with fat
- NAD+ follows circadian rhythm; peak synthesis AM
- Splitting doses maintains stable NAD+ throughout day