Source comparison
Comparison: Best Peptides for Growth Hormone Deficiency by Mechanism and Protocol Fit
CJC-1295 (with DAC) GHRH analogue. Extends natural GHRH signaling 6–8 days 30 mcg/kg or 1–2 mg fixed dose Once weekly None Best for sustained baseline GH elevation without daily injections. Ideal for hypothalamic dysfunction cases Ipamorelin Selective ghrelin
This comparison does not assign a generated winner or score.
- CJC-1295 (with DAC)
- GHRH analogue. Extends natural GHRH signaling
- 6–8 days
- 30 mcg/kg or 1–2 mg fixed dose
- Once weekly
- None
- Best for sustained baseline GH elevation without daily injections. Ideal for hypothalamic dysfunction cases
- Ipamorelin
- Selective ghrelin receptor agonist (GHS-R1a)
- 2 hours
- 200–300 mcg per dose
- 1–3 times daily
- Minimal to none
- Most versatile. Combines well with CJC-1295, no cortisol spike, preserves pulsatile GH pattern
- MK-677 (Ibutamoren)
- Oral ghrelin mimetic
- 24 hours
- 10–25 mg daily
- Once daily (oral)
- Minimal
- Only oral option. Increases appetite significantly, slight glucose elevation risk, no injection required
- Hexarelin
- Potent ghrelin agonist (GHS-R1a)
- 70 minutes
- 100–200 mcg per dose
- 2 times daily (cycled)
- Moderate. Transient prolactin
- Most potent per-dose GH release but desensitizes with continuous use. Cycle 4 weeks on, 4 weeks off
- Sermorelin
- Unmodified GHRH 1–29
- 8–12 minutes
- 200–500 mcg per dose
- 2–3 times daily
- Requires frequent dosing due to short half-life. Better as adjunct than monotherapy