Source comparison
Kisspeptin Dosage Protocol: Route and Endpoint Comparison
GnRH pulse restoration (amenorrhea) 0.3–1.0 nmol/kg Subcutaneous Every 90 min × 12–24 hrs 1 pulse per 90 min, peak 8–12 IU/L Mimics endogenous kisspeptin neuron firing; requires multi-dose commitment but produces physiological pulsatility Single LH surge induc
This comparison does not assign a generated winner or score.
- GnRH pulse restoration (amenorrhea)
- 0.3–1.0 nmol/kg
- Subcutaneous
- Every 90 min × 12–24 hrs
- 1 pulse per 90 min, peak 8–12 IU/L
- Mimics endogenous kisspeptin neuron firing; requires multi-dose commitment but produces physiological pulsatility
- Single LH surge induction (ovulation trigger)
- 3.2–6.4 nmol/kg
- Subcutaneous bolus
- Single dose
- Peak 15–25 IU/L at 45–60 min
- Supraphysiological but effective; risk of receptor desensitisation limits repeat dosing within 48 hours
- Metabolic signalling (insulin sensitivity)
- 4.0 nmol/kg
- IV infusion over 75 min
- Single infusion
- Modest LH elevation (secondary outcome)
- Maintains stable plasma concentration for metabolic endpoints; not optimised for reproductive outcomes
- Diagnostic GnRH neuron function testing
- 0.24 nmol/kg
- Peak 4–6 IU/L (healthy); <2 IU/L (impaired)
- Threshold dose differentiates functional vs impaired GnRH axis; lower cost per test than higher doses
- Chronic pulsatile therapy (hypogonadism)
- 0.5 nmol/kg
- Every 90 min via pump × 4 weeks
- Sustained LH 6–9 IU/L, testosterone normalisation
- Requires ambulatory infusion setup; closest approximation to endogenous kisspeptin secretion pattern