Source comparison
Melanotan-2 Dosage Guide: Protocol Comparison Table
The table below compares three MT2 dosing strategies: conservative (minimal side effects, slower pigmentation), standard (balanced), and aggressive (faster pigmentation, higher side effect frequency during loading). All three achieve similar endpoint pigmentat
This comparison does not assign a generated winner or score.
- The table below compares three MT2 dosing strategies: conservative (minimal side effects, slower pigmentation), standard (balanced), and aggressive (faster pigmentation, higher side effect frequency during loading). All three achieve similar endpoint pigmentation; the difference is speed and tolerability.
- Conservative
- 0.25mg daily for 7 days, then 0.5mg daily for 7 days
- 14 days
- 0.5mg twice weekly
- Low. Nausea and flushing in fewer than 20% of users
- 10–14 days
- Best for first-time users, Fitzpatrick types I–II, or those with low tolerance for GI side effects. Slower onset but highest completion rate.
- Standard
- 0.25mg daily for 3 days, then 0.5mg daily for 7–10 days
- 10–13 days
- 0.5–1mg twice weekly
- Moderate. Nausea in 30–40%, typically resolves by day 10
- 7–10 days
- Evidence-based starting point for most users. Balances speed and tolerability. Adjust based on individual response.
- Aggressive
- 0.5mg daily from day 1, escalate to 1mg daily by day 5
- 1mg twice weekly
- High. Nausea in 50–70%, spontaneous erections common in males, flushing frequent
- 5–7 days
- Not recommended for naïve users. Reserved for experienced users who have completed at least one prior MT2 cycle and tolerated 1mg doses previously.
- Bottom Line: The standard protocol (0.25mg × 3 days, then 0.5mg × 7–10 days) represents the optimal risk-to-benefit ratio for most research applications. Conservative protocols reduce side effect frequency at the cost of slower onset. Aggressive protocols deliver faster pigmentation but have 40–50% higher discontinuation rates due to intolerable nausea during loading. Start conservative. You can always escalate, but you cannot reverse a week of severe nausea.