Source comparison
Sermorelin 20s Age Specific Protocol: Full Comparison
Starting Dose 200 mcg nightly 500 mcg nightly 750–1000 mcg nightly Younger populations require 60% lower starting doses due to intact GHRH receptor density and higher baseline somatotroph responsiveness Maximum Effective Dose 300 mcg nightly 1000 mcg nightly 1
This comparison does not assign a generated winner or score.
- Starting Dose
- 200 mcg nightly
- 500 mcg nightly
- 750–1000 mcg nightly
- Younger populations require 60% lower starting doses due to intact GHRH receptor density and higher baseline somatotroph responsiveness
- Maximum Effective Dose
- 300 mcg nightly
- 1000 mcg nightly
- 1500 mcg nightly
- Doses above 400 mcg in the 20s age group trigger somatostatin rebound without proportional IGF-1 elevation
- Administration Timing
- 30–60 min pre-sleep
- Timing is consistent across ages to align with nocturnal GH surge during slow-wave sleep
- Objective
- Pulse amplification
- Pulse restoration
- Replacement therapy
- Protocol design shifts from optimising existing output to compensating for age-related decline
- Expected IGF-1 Increase
- 15–25% above baseline
- 30–50% above baseline
- 40–60% above baseline
- Younger subjects start from higher baselines. Absolute ng/mL gains are smaller but percentage preservation matters more long-term
- Reconstitution Volume (5mg vial)
- 2 mL bacteriostatic water
- Concentration consistency simplifies dose calculation across protocols