Source comparison
Sermorelin Protocol Comparison — Dose Schedules and Expected Outcomes
Conservative Initiation 200mcg nightly 5 nights/week 20–35ng/mL from baseline First-time peptide users, baseline IGF-1 >150ng/mL, or age >55 with unknown GH reserve Minimises side effects, allows receptor sensitivity assessment, lower cost during trial phase.
This comparison does not assign a generated winner or score.
- Conservative Initiation
- 200mcg nightly
- 5 nights/week
- 20–35ng/mL from baseline
- First-time peptide users, baseline IGF-1 >150ng/mL, or age >55 with unknown GH reserve
- Minimises side effects, allows receptor sensitivity assessment, lower cost during trial phase. Best for risk-averse patients
- Standard Maintenance
- 300mcg nightly
- 6–7 nights/week
- 40–65ng/mL from baseline
- Most adult patients aged 35–55 with baseline IGF-1 120–180ng/mL after successful 8-week initiation
- Achieves target IGF-1 restoration with manageable injection burden and cost. Most physicians default to this after dose-finding phase
- Aggressive Optimisation
- 500mcg nightly
- 7 nights/week
- 60–90ng/mL from baseline
- Severe GH deficiency (baseline IGF-1 <120ng/mL), competitive athletes in off-season, or body recomposition protocols under medical supervision
- Maximum receptor stimulation before diminishing returns, higher cost and injection site reaction risk. Reserve for patients who tolerate 300mcg without issues