Source comparison
Women 35-45 Sermorelin Protocol: Dosing Comparison
Starting Dose 200mcg nightly, weeks 1-4 300mcg nightly, weeks 1-2 500mcg from week 1 Conservative allows receptor re-sensitization. Best for women with prior GH/peptide exposure or metabolic dysfunction Escalation Timeline +100mcg every 4 weeks +100mcg every 2
This comparison does not assign a generated winner or score.
- Starting Dose
- 200mcg nightly, weeks 1-4
- 300mcg nightly, weeks 1-2
- 500mcg from week 1
- Conservative allows receptor re-sensitization. Best for women with prior GH/peptide exposure or metabolic dysfunction
- Escalation Timeline
- +100mcg every 4 weeks
- +100mcg every 2 weeks
- No escalation
- Standard 2-week steps balance efficacy with side effect risk. Most women tolerate this well
- Maintenance Dose
- 300mcg 5 nights/week
- 500mcg 5-7 nights/week
- 500-1000mcg nightly
- Doses above 500mcg do not proportionally increase IGF-1. Diminishing returns beyond this threshold
- Injection Timing
- 60 min pre-bed
- 30-45 min pre-bed
- Immediately pre-bed
- 30-45 min window aligns GH pulse with sleep onset. Earlier timing risks pulse misalignment
- Expected IGF-1 Elevation (12 weeks)
- +20-40 ng/mL
- +30-60 ng/mL
- +40-70 ng/mL
- IGF-1 gains plateau around 500mcg. Higher doses increase side effect risk without meaningful additional benefit