Source comparison
TB-500 Research Aging Biomarkers: What's Measured vs What Matters
Inflammatory Cytokines 30–40% reduction in IL-6, TNF-alpha in rodent models Serum ELISA, multiplex cytokine assay High. Chronic inflammation predicts CVD, dementia, frailty Strong preclinical evidence; human data needed Telomere Length 12–15% preservation in m
This comparison does not assign a generated winner or score.
- Inflammatory Cytokines
- 30–40% reduction in IL-6, TNF-alpha in rodent models
- Serum ELISA, multiplex cytokine assay
- High. Chronic inflammation predicts CVD, dementia, frailty
- Strong preclinical evidence; human data needed
- Telomere Length
- 12–15% preservation in muscle/cardiac tissue (rodents)
- qPCR telomere length assay
- Moderate. Tissue-specific, doesn't extend to all organs
- Suggestive but not conclusive
- Mitochondrial Function
- 28% improvement in membrane potential (cardiomyocytes)
- JC-1 fluorescence, oxygen consumption rate
- High. Mitochondrial decline drives aging in most tissues
- Mechanism established; dose-response unclear in humans
- Vascular Endothelial Function
- 18% improvement in FMD, 40% increase in EPC counts (mice)
- Flow-mediated dilation, flow cytometry
- Very high. Vascular aging precedes organ decline
- Most promising aging-relevant outcome
- Epigenetic Age (DNAm Clocks)
- No data available. Not yet tested
- Horvath clock, GrimAge, PhenoAge
- Potentially transformative if tested
- Critical gap in current research