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TB-500 Research Heart Rate Variability Notes: Trial Comparisons

Cardiovascular Research (2020) Rat MI model 12 mg/kg Single dose 6h post-MI +29% +27% Day 14 post-injury Journal of Cardiovascular Pharmacology (2022) 18 mg/kg 3 doses over 7 days +31% +34% Day 21 post-injury Peptides (2021) 10 mg/kg Single dose 24h post-MI +2

This comparison does not assign a generated winner or score.

  • Cardiovascular Research (2020)
  • Rat MI model
  • 12 mg/kg
  • Single dose 6h post-MI
  • +29%
  • +27%
  • Day 14 post-injury
  • Journal of Cardiovascular Pharmacology (2022)
  • 18 mg/kg
  • 3 doses over 7 days
  • +31%
  • +34%
  • Day 21 post-injury
  • Peptides (2021)
  • 10 mg/kg
  • Single dose 24h post-MI
  • +28%
  • +23%
  • Basic Research in Cardiology (2019)
  • Canine ischemia-reperfusion
  • 20 mg/kg
  • Single dose pre-ischemia
  • +19%
  • +22%
  • Day 7 post-reperfusion
  • American Journal of Physiology (2023)
  • Rat chronic stress model
  • 15 mg/kg
  • 5 doses over 14 days
  • +26%
  • Day 21 post-treatment start
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