Source comparison
TB-500 Research Mental Performance Comparison
Stroke recovery (rodent) Neuroblast migration increased 40–60%; NeuN+ cells doubled at lesion border (U. Pittsburgh 2021) Strong preclinical Structural repair only. No behaviour tested Neuroprotective in injury models; cognitive enhancement extrapolation unsup
This comparison does not assign a generated winner or score.
- Stroke recovery (rodent)
- Neuroblast migration increased 40–60%; NeuN+ cells doubled at lesion border (U. Pittsburgh 2021)
- Strong preclinical
- Structural repair only. No behaviour tested
- Neuroprotective in injury models; cognitive enhancement extrapolation unsupported
- Traumatic brain injury (rodent)
- Lesion volume reduced 30%; Morris water maze latency preserved vs injured controls (Brain Research 2020)
- Moderate preclinical
- Prevention of decline, not enhancement
- Prevents injury-induced impairment; doesn't improve healthy baseline
- Chemotherapy-induced impairment (mouse)
- Dendritic spine density preserved; water maze performance matched healthy controls (Brain Research 2020)
- Neuroprotection against toxicity
- Protective effect under insult; no data in unchallenged systems
- Human cognitive performance
- No published trials
- None
- Unknown
- Entirely speculative. Mechanism plausibility does not equal demonstrated efficacy
- Neuroinflammation (in vitro)
- NF-κB signalling reduced; microglial activation decreased at 100–500 ng/mL
- Strong mechanistic
- Indirect. Inflammation impairs plasticity
- Anti-inflammatory effects confirmed at cellular level; translation to human dosing unknown