Source comparison
Best Kisspeptin Dosage for Fertility: Clinical Trial Comparison
Hypothalamic Amenorrhea (HA) Continuous IV infusion 0.01–0.04 nmol/kg/hour 8–12 weeks Resumption of menstrual cycles Pulsatile delivery matches endogenous KISS1 neuron firing. Most physiologic approach for HPG axis restart IVF Ovulation Trigger Single IV bolus
This comparison does not assign a generated winner or score.
- Hypothalamic Amenorrhea (HA)
- Continuous IV infusion
- 0.01–0.04 nmol/kg/hour
- 8–12 weeks
- Resumption of menstrual cycles
- Pulsatile delivery matches endogenous KISS1 neuron firing. Most physiologic approach for HPG axis restart
- IVF Ovulation Trigger
- Single IV bolus
- 3.2–6.4 nmol/kg
- One-time administration 36 hours pre-retrieval
- LH surge adequate for oocyte maturation
- Comparable efficacy to hCG with dramatically lower OHSS risk. Preferred in high-responder patients
- PCOS Anovulation
- IV bolus (experimental)
- 1.6–3.2 nmol/kg on cycle day 12–14
- Single cycle
- Ovulation confirmation via progesterone >3 ng/mL
- Limited evidence. Mechanism unclear without concurrent insulin sensitisation
- Male Hypogonadotropic Hypogonadism
- Subcutaneous injection
- 9.6 nmol/kg twice weekly
- 12–24 weeks
- Testosterone normalisation and spermatogenesis
- Early-phase evidence only. Not FDA-approved for this indication